Variable risk of second primary malignancy in multiple myeloma patients of different ethnic subgroups
نویسندگان
چکیده
منابع مشابه
Variable risk of second primary malignancy in multiple myeloma patients of different ethnic subgroups
Second primary malignancies (SPMs) among multiple myeloma (MM) patients have been reported with an estimated incidence varying from 1 to 15%. We have previously reported that significant disparity exists in MM survival across patients of different ethnicities. We undertook a Surveillance Epidemiology and End Results-based analysis to describe the incidence of SPMs among MM patients of different...
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Recent studies have reported an increased risk of second primary malignancies (SPM) following multiple myeloma (MM) diagnosis associated with novel anti-myeloma treatments. We evaluated the risk of SPM among 36 491 MM cases reported to the Surveillance, Epidemiology, and End Results program (SEER) between 1973 and 2008. We calculated overall and site-specific standardized incidence ratio (SIR) ...
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In a retrospective pooled analysis of 11 clinical trials of lenalidomide-based therapy for relapsed/refractory multiple myeloma (MM; N = 3846), the overall incidence rate (IR, events per 100 patient-years) of second primary malignancies (SPMs) was 3.62. IR of invasive (hematologic and solid tumor) SPMs was 2.08, consistent with the background incidence of developing cancer. In a separate analys...
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BACKGROUND Improving therapies means longer survival for multiple myeloma (MM) patients. We hypothesized that these patients are at an increased risk for a secondary malignancy. OBJECTIVES (i) To investigate the epidemiology and site-specific risk of second primary cancers (SPCs) in patients with MM (ii) To investigate the factors affecting survival in MM patients with SPCs. DESIGN This was...
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CD44 variant isoforms (CD44v) are generated by alternative splicing of the nuclear RNA resulting in the expression of additional protein domains in the extracellular region of the CD44 standard molecule (CD44s). In multiple myeloma (MM), CD44 mediates binding of tumor cells to stroma and regulates interleukin-6 production. To evaluate the role of CD44v isoforms in MM, CD44v expression was analy...
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ژورنال
عنوان ژورنال: Blood Cancer Journal
سال: 2014
ISSN: 2044-5385
DOI: 10.1038/bcj.2014.63